Shankar Balasubramanian publications

Small-molecule-mediated G-quadruplex isolation from human cells
Muller S;Kumari S;Rodriguez R;Balasubramanian S
Nat Chem 2011; 2 (12):1095-1098.
PubMed;  DOI: 10.1038/NCHEM.842.

Distinct functions of maternal and somatic Pat1 protein paralogs
Marnef A;Maldonado M;Bugaut A;Balasubramanian S;Kress M;Weil D;Standart N
RNA 2010; 16 (11):2094-2107.
UKPubMed (open access);  PubMed;  DOI: 10.1261/rna.2295410.

Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines
Bejugam M;Gunaratnam M;Muller S;Sanders DA;Sewitz S;Fletcher JA;Neidle S;Balasubramanian S
ACS Med Chem Lett 2010; 1 (7):306-310.
DOI: 10.1021/ml100062z.

The BCL-2 5 ' Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression
Shahid R;Bugaut A;Balasubramanian S
Biochemistry 2010; 49 (38):8300-8306.
PubMed;  DOI: 10.1021/bi100957h.

Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
Bugaut A;Rodriguez R;Kumari S;Hsu STD;Balasubramanian S
Org Biomol Chem 2010; 8 (12):2771-2776.
PubMed;  DOI: 10.1039/c002418j.

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression
Fernando H;Sewitz S;Darot J;Tavare S;Huppert JL;Balasubramanian S
Nucleic Acids Res 2009; 37 (20):6716-6722.
UKPubMed (open access);  PubMed;  DOI: 10.1093/nar/gkp740.

A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression
Waller ZAE;Sewitz SA;Hsu STD;Balasubramanian S
J Am Chem Soc 2009; 131 (35):12628-12633.
PubMed;  DOI: 10.1021/ja901892u.

G-quadruplex nucleic acids as therapeutic targets
Balasubramanian S;Neidle S
Curr Opin Chem Biol 2009; 13 (3):345-353.
UKPubMed (open access);  PubMed;  DOI: 10.1016/j.cbpa.2009.04.637.

Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
Redman JE;Granadino-Roldan JM;Schouten JA;Ladame S;Reszka AP;Neidle S;Balasubramanian S
Org Biomol Chem 2009; 7 (1):76-84.
UKPubMed (open access);  PubMed;  DOI: 10.1039/b814682a.

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition
Muller S;Pantos GD;Rodriguez R;Balasubramanian S
Chem Commun (Camb) 2009; (1):80-82.
UKPubMed (open access);  PubMed;  DOI: 10.1039/b816861j.

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres
Rodriguez R;Muller S;Yeoman JA;Trentesaux C;Riou JF;Balasubramanian S
J Am Chem Soc 2008; 130 (47):15758-15759.
UKPubMed (open access);  PubMed;  DOI: 10.1021/ja805615w.

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts
London TBC;Barber LJ;Mosedale G;Kelly GP;Balasubramanian S;Hickson ID;Boulton SJ;Hiom K
J Biol Chem 2008; 283 (52):36132-36139.
UKPubMed (open access);  PubMed;  DOI: 10.1074/jbc.M808152200.

Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5 ' UTR of the NRAS Proto-oncogene
Kumari S;Bugaut A;Balasubramanian S
Biochemistry 2008; 47 (48):12664-12669.
UKPubMed (open access);  PubMed;  DOI: 10.1021/bi8010797.

G-quadruplexes: the beginning and end of UTRs
Huppert JL;Bugaut A;Kumari S;Balasubramanian S
Nucleic Acids Res 2008; 36 (19):6260-6268.
UKPubMed (open access);  PubMed;  DOI: 10.1093/nar/gkn511.

Selective recognition of a DNA G-quadruplex by an engineered antibody
Fernando H;Rodriguez R;Balasubramanian S
Biochemistry 2008; 47 (36):9365-9371.
UKPubMed (open access);  PubMed;  DOI: 10.1021/bi800983u.

G-quadruplex recognition by bis-indole carboxamides
Dash J;Shirude PS;Balasubramanian S
Chem Commun (Camb) 2008; (26):3055-3057.
UKPubMed (open access);  PubMed;  DOI: 10.1039/b806042h.

Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC
Shirude PS;Ying LM;Balasubramanian S
Chem Commun (Camb) 2008; (17):2007-2009.
UKPubMed (open access);  PubMed;  DOI: 10.1039/b801465e.

Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition
Waller ZAE;Shirude PS;Rodriguez R;Balasubramanian S
Chem Commun (Camb) 2008; (12):1467-1469.
UKPubMed (open access);  PubMed;  DOI: 10.1039/b718854d.

A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes
Bugaut A;Balasubramanian S
Biochemistry 2008; 47 (2):689-697.
UKPubMed (open access);  PubMed;  DOI: 10.1021/bi701873c.

Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: Small molecule regulation of c-kit oncogene expression
Bejugam M;Sewitz S;Shirude PS;Rodriguez R;Shahid R;Balasubramanian S
J Am Chem Soc 2007; 129 (43):12926-12927.
UKPubMed (open access);  DOI: 10.1021/ja075881p.

Macrocyclic and helical oligoamides as a new class of g-quadruplex ligands
Shirude PS;Gillies ER;Ladame S;Godde F;Shin-Ya K;Huc I;Balasubramanian S
J Am Chem Soc 2007; 129 (39):11890-11891.
UKPubMed (open access);  DOI: 10.1021/ja073775h.

Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction
Rodriguez R;Pantos GD;Goncalves DPN;Sanders JKM;Balasubramanian S
Angew Chem Int Ed Engl 2007; 46 (28):5405-5407.
UKPubMed (open access);  PubMed;  DOI: 10.1002/anie.200605075.

An RNA G-quadruplex in the 5 ' UTR of the NRAS proto-oncogene modulates translation
Kumari S;Bugaut A;Huppert JL;Balasubramanian S
Nat Chem Biol 2007; 3 (4):218-221.
UKPubMed (open access);  DOI: 10.1038/nchembio864.

G-quadruplexes in promoters throughout the human genome
Huppert JL;Balasubramanian S
Nucleic Acids Res 2007; 35 (2):406-413.
UKPubMed (open access);  DOI: 10.1093/nar/gkl1057.

Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library
Redman JE;Ladame S;Reszka AP;Neidle S;Balasubramanian S
Org Biomol Chem 2006; 4 (23):4364-4369.
UKPubMed (open access);  DOI: 10.1039/b611716c.

Tetramethylpyridiniumporphyrazines - a new class of G-quadruplex inducing and stabilising ligands
Goncalves DPN;Rodriguez R;Balasubramanian S;Sanders JKM
Chem Commun (Camb) 2006; (45):4685-4687.
UKPubMed (open access);  DOI: 10.1039/b611731g.

Oxazole-based peptide macrocycles: A new class of G-quadruplex binding ligands
Jantos K;Rodriguez R;Ladame S;Shirude PS;Balasubramanian S
J Am Chem Soc 2006; 128 (42):13662-13663.
UKPubMed (open access);  DOI: 10.1021/ja064713e.

Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins
Goncalves DPN;Ladame S;Balasubramanian S;Sanders JKM
Org Biomol Chem 2006; 4 (17):3337-3342.
UKPubMed (open access);  DOI: 10.1039/b608494j.

Investigating a quadruplex-ligand interaction by unfolding kinetics
Green JJ;Ladame S;Ying LM;Klenerman D;Balasubramanian S
J Am Chem Soc 2006; 128 (30):9809-9812.
UKPubMed (open access); 

A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene
Fernando H;Reszka AP;Huppert J;Ladame S;Rankin S;Venkitaraman AR;Neidle S;Balasubramanian S
Biochemistry 2006; 45 (25):7854-7860.
UKPubMed (open access);  DOI: 10.1021/bi0601510.

Exploring the recognition of quadruplex DNA by an engineered Cys(2)-His(2) zinc finger protein
Ladame S;Schouten JA;Roldan J;Redman JE;Neidle S;Balasubramanian S
Biochemistry 2006; 45 (5):1393-1399.

Putative DNA wuadruplex formation within the human c-kit oncogene
Rankin S;Reszka AP;Huppert J;Zloh M;Parkinson GN;Todd AK;Ladame S;Balasubramanian S;Neidle S
J Am Chem Soc 2005; 127 (30):10584-10589.
UKPubMed (open access);  DOI: 10.1021/ja050823u.

Loop-length-dependent folding of G-quadruplexes
Hazel P;Huppert J;Balasubramanian S;Neidle S
J Am Chem Soc 2004; 126 (50):16405-16415.

Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes
Patel SD;Isalan M;Gavory G;Ladame S;Choo Y;Balasubramanian S
Biochemistry 2004; 43 (42):13452-13458.

Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform
Ladame S;Schouten JA;Stuart J;Roldan J;Neidle S;Balasubramanian S
Org Biomol Chem 2004; 2 (20):2925-2931.