Brindle laboratory publications

Primary research
Bird-Lieberman EL, Neves AA, Lao-Sirieix P, O'Donovan M, Novelli M, Lovat LB, Eng WS, Mahal LK, Brindle KM, Fitzgerald RC. Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus. Nat Med. 2012 Jan 15;18(2):315-21.

Bohndiek SE, Kettunen MI, Hu DE, Brindle KM. Hyperpolarized 13C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization. Cancer Res. 2012 Jan 5;72(4):854-64.

Primary research papers
Bohndiek SE, Kettunen MI, Hu DE, Kennedy BW, Boren J, Gallagher FA, Brindle KM. Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo. J Am Chem Soc. 2011; 133: 11795-801

Crossan GP, van der Weyden L, Rosado IV, Langevin F, Gaillard PH, McIntyre RE, Gallagher F, Kettunen MI, Lewis DY, Brindle K, Arends MJ, Adams DJ, Patel KJ. Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia. Nat Genet. 2011; 43: 147-52

Day SE, Kettunen MI, Cherukuri MK, Mitchell JB, Lizak MJ, Morris HD, Matsumoto S, Koretsky AP, Brindle KM. Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1-(13) C]pyruvate and (13) C magnetic resonance spectroscopic imaging. Magn Reson Med. 2011; 65: 557-63

Gallagher FA, Kettunen MI, Day SE, Hu DE, Karlsson M, Gisselsson A, Lerche MH, Brindle KM. Detection of tumor glutamate metabolism in vivo using (13) C magnetic resonance spectroscopy and hyperpolarized [1-(13) C]glutamate. Magn Reson Med. 2011; 66: 18-23

Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H, Zecchini V, Smith DM, Denicola GM, Mathews N, Osborne M, Hadfield J, Macarthur S, Adryan B, Lyons SK, Brindle KM, Griffiths J, Gleave ME, Rennie PS, Neal DE, Mills IG. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J. 2011; 30: 2719-33

Neves AA, Stockmann H, Harmston RR, Pryor HJ, Alam IS, Ireland-Zecchini H, Lewis DY, Lyons SK, Leeper FJ, Brindle KM. Imaging sialylated tumor cell glycans in vivo. FASEB J. 2011; 25: 2528-37

Sleigh A, Raymond-Barker P, Thackray K, Porter D, Hatunic M, Vottero A, Burren C, Mitchell C, McIntyre M, Brage S, Carpenter TA, Murgatroyd PR, Brindle KM, Kemp GJ, O'Rahilly S, Semple RK, Savage DB. Mitochondrial dysfunction in patients with primary congenital insulin resistance. J Clin Invest. 2011; 121: 2457-61

Stockmann H, Neves AA, Day HA, Stairs S, Brindle KM, Leeper FJ. (E,E)-1,5-Cyclooctadiene: a small and fast click-chemistry multitalent. Chem Commun (Camb). 2011; 47: 7203-5

Stockmann H, Neves AA, Stairs S, Brindle KM, Leeper FJ. Exploring isonitrile-based click chemistry for ligation with biomolecules. Org Biomol Chem. 2011; 9: 7303-5

Stockmann H, Neves AA, Stairs S, Ireland-Zecchini H, Brindle KM, Leeper FJ. Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells. Chemical Science. 2011; 2: 932-6

Witney TH, Kettunen MI, Brindle KM. Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells. J Biol Chem. 2011; 286: 24572-80

Other publications
Brindle KM, Bohndiek SE, Gallagher FA, Kettunen MI. Tumor imaging using hyperpolarized (13) C magnetic resonance spectroscopy. Magn Reson Med. 2011; 66: 505-19

Gallagher FA, Bohndiek SE, Kettunen MI, Lewis DY, Soloviev D, Brindle KM. Hyperpolarized 13C MRI and PET: In vivo tumor biochemistry. J Nucl Med. 2011; 52: 1333-6

Gallagher FA, Kettunen MI, Brindle KM. Imaging pH with hyperpolarized (13) C. NMR Biomed. 2011; 24: 1006-15

Kurhanewicz J, Vigneron DB, Brindle K, Chekmenev EY, Comment A, Cunningham CH, Deberardinis RJ, Green GG, Leach MO, Rajan SS, Rizi RR, Ross BD, Warren WS, Malloy CR. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia. 2011; 13: 81-97

Alam IS, Neves AA, Witney TH, Boren J, Brindle KM. Comparison of the C2A domain of synaptotagmin-I and annexin-V as probes for detecting cell death. Bioconjug Chem. 2010 Apr 19;21:884-91.

Bird-Lieberman EL, Neves AA, O'Donovan M, Lao-Sirieix P, Brindle KM, Fitzgerald RC. Potential Application of Lectins As Molecular Imaging Tools to Detect Dysplasia in Barrett's Oesophagus Endoscopically. Gastrointest Endosc. [Meeting Abstract]. 2010 Apr;71(5):AB145-AB.

Bohndiek SE, Brindle KM. Imaging and 'omic' methods for the molecular diagnosis of cancer. Expert Rev Mol Diagn. 2010 May;10(4):417-34.

Bohndiek SE, Kettunen MI, Hu DE, Witney TH, Kennedy BW, Gallagher FA, Brindle KM. Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy. Mol Cancer Ther. 2010 Dec;9(12):3278-88.

Day SE, Kettunen MI, Cherukuri MK, Mitchell JB, Lizak MJ, Morris HD, Matsumoto S, Koretsky AP, Brindle KM. Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1-(13)C]pyruvate and (13)C magnetic resonance spectroscopic imaging. Magn Reson Med. 2010 Nov 16:Epub 16 Nov.

Kettunen MI, Hu DE, Witney TH, McLaughlin R, Gallagher FA, Bohndiek SE, Day SE, Brindle KM. Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma. Magn Reson Med. 2010 Apr;63(4):872-80.

Witney TH, Brindle KM. Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy. Biochem Soc Trans. 2010 Oct;38(5):1220-4.

Witney TH, Kettunen MI, Hu DE, Gallagher FA, Bohndiek SE, Napolitano R, Brindle KM. Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-(13)C]pyruvate and [1,4-(13)C(2)]fumarate. Br J Cancer. 2010 Oct 5;103:1400-6.

Primary Research Papers
Barbera M, Kettunen MI, Caputo A, Hu D-E, Gobbi S, Brindle KM, Carrara M. Immune-modulating and anti-vascular activities of two xanthenone acetic acid analogues: A comparative study to DMXAA. International Journal of Oncology 2009; 34: 273-9

Canuto HC, McLachlan C, Kettunen MI, Velic M, Krishnan AS, Neves AA, de Backer M, Hu DE, Hobson MP, Brindle KM. Characterization of image heterogeneity using 2D Minkowski functionals increases the sensitivity of detection of a targeted MRI contrast agent. Magnetic Resonance Medicine 2009; 61: 1218-24

Gallagher FA, Kettunen MI,  Hu DE, Jensen RJ, in ‘t Zandt R, Karlsson M, Gisselsson A, Nelson SK, Witney TH, Bohndiek, SE, Hansson G, Peitersen T, Lerche MH, Brindle KM. Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors. Proceedings of the National Academy of Sciences USA 2009; 106: 19801-6

Witney TH, Kettunen MI, Day SE, Hu DE, Neves AA, Gallagher FA, Fulton SM, Brindle KM. A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized 13C-labeled pyruvate utilization as methods for detecting tumor response to treatment. Neoplasia 2009; 11: 574-82

Other Publications
Gallagher FA, Kettunen MI, Brindle, KM. Biomedical applications of hyperpolarized 13C magnetic resonance imaging. Progress in NMR Spectroscopy 2009; 55: 285-82

Primary Research Papers
Gallagher FA, Kettunen MI, Day SE, Hu D-E, Ardenkjær-Larsen JH, Zandt R, Jensen PR, Karlsson M, Golman K, Lerche MH, Brindle KM. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Nature 2008; 453:940-3

Gallagher FA, Kettunen MI, Day SE, Lerche MH, Brindle KM. 13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma using hyperpolarised 13C-labelled glutamine. Magnetic Resonance Medicine 2008; 60:253-7

Krishnan AS, Neves AA, de Backer MM, Hu DE, Davletov B, Kettunen MI, Brindle KM. Detection of cell death in tumours by using MR imaging and a gadolinium-based targeted contrast agent. Radiology 2008; 246:854-62

Other Publications
Brindle KM. New approaches for imaging tumour responses to treatment. Nature Reviews Cancer 2008; 8:94-107

Primary Research Papers
Bundy JG, Papp B, Harmston R, Browne RA, Clayson EM, Burton N, Reece RJ, Oliver SG, Brindle KM. Evaluation of predicted network modules in yeast metabolism using NMR-based metabolite profiling. Genome Research 2007; 17:510-519

Day SE, Kettunen MI, Gallagher FA, Hu D-E, Lerche M, Wolber J, Golman K, Ardenkjaer-Larsen JH, Brindle KM. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nature Medicine 2007; 13:1382-1387

Neves AA, Krishnan AS, Kettunen MI, Hu DE, de Backer MM, Davletov B, Brindle KM. A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging. Nano Letters 2007; 7:1419-1423