John Griffiths publications

Prostate Cancer Metabolite Quantification Relative To Water In H-1-MRSI In Vivo At 3 Tesla
McLean MA;Barrett T;Gnanapragasam VJ;Priest AN;Joubert I;Lomas DJ;Neal DE;Griffiths JR;Sala E
Magn Reson Med 2011; 65 (4 ):914-919.
PubMed;  DOI: 10.1002/mrm.22703.

Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts.
Biswas S;Troy H;Leek R;Chung YL;Li JL;Raval RR;Turley H;Gatter K;Pezzella F;Griffiths JR;Stubbs M;Harris AL
J Oncol 2010; 2010 ():757908.
UKPubMed (open access);  PubMed;  DOI: 10.1155/2010/757908.

The altered metabolism of tumors: HIF-1 and its role in the Warburg effect.
Stubbs M;Griffiths JR
Adv Enzyme Regul 2010; 50 (1):44-55.
PubMed;  DOI: 10.1016/j.advenzreg.2009.10.027.

Can localised (19)F magnetic resonance spectroscopy pharmacokinetics of 5FU in colorectal metastases predict clinical response?
McIntyre DJ;Howe FA;Ladroue C;Lofts F;Stubbs M;Griffiths JR
Cancer Chemother Pharmacol 2010; ():.
PubMed;  DOI: 10.1007/s00280-010-1438-2.

Combined Use of Neuroradiology and H-1-MR Spectroscopy May Provide an Intervention Limiting Diagnosis of Glioblastoma Multiforme
Fellows GA;Wright AJ;Sibtain NA;Rich P;Opstad KS;McIntyre DJO;Bell BA;Griffiths JR;Howe FA
J Magn Reson Imaging 2010; 32 (5):1038-1044.
PubMed;  DOI: 10.1002/jmri.22350.

Pattern Recognition of MRSI Data Shows Regions of Glioma Growth That Agree With DTI Markers of Brain Tumor Infiltration
Wright AJ;Fellows G;Byrnes TJ;Opstad KS;McIntyre DJO;Griffiths JR;Bell BA;Clark CA;Barrick TR;Howe FA
Magn Reson Med 2009; 62 (6):1646-1651.
PubMed;  DOI: 10.1002/mrm.22163.

Magnetic resonance spectroscopy: principles and applications in neurosurgery
McLean MA;Cross JJ
Br J Neurosurg 2009; 23 (1):5-13.
PubMed;  DOI: 10.1080/02688690802491673.

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Olive KP;Jacobetz MA;Davidson CJ;Gopinathan A;McIntyre D;Honess D;Madhu B;Goldgraben MA;Caldwell ME;Allard D;Frese KK;DeNicola G;Feig C;Combs C;Winter SP;Ireland-Zecchini H;Reichelt S;Howat WJ;Chang A;Dhara M;Wang LF;Ruckert F;Grutzmann R;Pilarsky C;Izeradjene K;Hingorani SR;Huang P;Davies SE;Plunkett W;Egorin M;Hruban RH;Whitebread N;McGovern K;Adams J;Iacobuzio-Donahue C;Griffiths J;Tuveson DA
Science 2009; 324 (5933):1457-1461.
PubMed; 

In Vivo P-31 Magnetic Resonance Spectroscopy Using a Needle Microcoil
Howe FA;Syms RRA;Ahmad MM;Rodrigues LM;Griffiths JR;Young IR
Magn Reson Med 2009; 61 (5):1238-1241.
PubMed;  DOI: 10.1002/mrm.21941.

Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts
Mayr M;Liem D;Zhang J;Li XH;Avliyakuiov NK;Yang JI;Young G;Vondriska TM;Ladroue C;Madhu B;Griffiths JR;Gomes A;Xu QB;Ping PP
J Mol Cell Cardiol 2009; 46 (2):268-277.

Diagnosing brain cancer without a biopsy - the eTUMOUR project
Griffiths JR
Public Serv Rev Eur Union 2008; ():.

A picture of health
Griffiths JR
Public Serv Rev Eur Union 2008; ():16.

Effect of Gd-DTPA-BMA on Choline Signals of HT29 Tumors Detected by In Vivo H-1 MRS
Madhu B;Robinson SP;Howe FA;Griffiths JR
J Magn Reson Imaging 2008; 28 (5):1201-1208.
PubMed;  DOI: 10.1002/jmri.21577.

An assessment of the effects of sample ischaemia and spinning time on the metabolic profile of brain tumour biopsy specimens as determined by high-resolution magic angle spinning H-1 NMR
Opstad KS;Bell BA;Griffiths JR;Howe FA
NMR Biomed 2008; 21 (10):1138-1147.
PubMed;  DOI: 10.1002/nbm.1296.

Longitudinal In Vivo Susceptibility Contrast MRI Measurements of LS174T Colorectal Liver Metastasis in Nude Mice
Kalber TL;Waterton JC;Griffiths JR;Ryan AJ;Robinson SP
J Magn Reson Imaging 2008; 28 (6):1451-1458.

Toward Accurate Quantification of Metabolites, Lipids, and Macromolecules in HRMAS Spectra of Human Brain Tumor Biopsies Using LCModel
Opstad KS;Bell BA;Griffiths JR;Howe FA
Magn Reson Med 2008; 60 (5):1237-1242.
PubMed;  DOI: 10.1002/mrm.21496.

An investigation of human brain tumour lipids by high-resolution magic angle spinning H-1 MRS and histological analysis
Opstad KS;Bell BA;Griffiths JR;Howe FA
NMR Biomed 2008; 21 (7):677-685.
PubMed;  DOI: 10.1002/nbm.1239.

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Porstmann T;Santos CR;Griffiths B;Cully M;Wu M;Leevers S;Griffiths JR;Chung YL;Schulze A
Cell Metab 2008; 8 (3):224-236.
UKPubMed (open access);  PubMed;  DOI: 10.1016/j.cmet.2008.07.007.

Vessel size index magnetic resonance imaging to monitor the effect of antivascular treatment in a rodent tumor model
Howe FA;McPhail LD;Griffiths JR;McIntyre DJO;Robinson SP
Int J Radiat Oncol Biol Phys 2008; 71 (5):1470-1476.
PubMed;  DOI: 10.1016/j.ijrobp.2008.04.027.

Automated quality control protocol for MR spectra of brain tumors
Wright AJ;Arus C;Wijnen JP;Moreno-Torres A;Griffiths JR;Celda B;Howe FA
Magn Reson Med 2008; 59 (6):1274-1281.
PubMed;  DOI: 10.1002/mrm.21533.

Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice
Mayr M;Zampetaki A;Sidibe A;Mayr U;Yin XK;De Souza AI;Chung YL;Madhu B;Quax PH;Hu YH;Griffiths JR;Xu QB
Circ Res 2008; 102 (9):1046-1056.

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts
Chung YL;Troy H;Kristeleit R;Aherne W;Jackson E;Atadja P;Griffiths JR;Judson IR;Workman P;Leach MO;Beloueche-Babari M
Neoplasia 2008; 10 (4):303-313.
UKPubMed (open access);  PubMed; 

Combined metabolomic and proteomic analysis of human atrial fibrillation
Mayr M;Yusuf S;Weir G;Chung YL;Mayr U;Yin X;Ladroue C;Madhu B;Roberts N;De Souza A;Fredericks S;Stubbs M;Griffiths JR;Jahangiri M;Xu QB;Camm AJ
J Am Coll Cardiol 2008; 51 (5 Spec Iss):585-594.

Apparent T-2 relaxation times of lipid and macromolecules: A study of high-grade tumor spectra
Opstad KS;Griffiths JR;Bell BA;Howe FA
J Magn Reson Imaging 2008; 27 (1):178-184.

Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies
Evans A;Bates V;Troy H;Hewitt S;Holbeck S;Chung YL;Phillips R;Stubbs M;Griffiths J;Airley R
Cancer Chemother Pharmacol 2008; 61 (3):377-393.

Linear discriminant analysis of brain tumour H-1 MR spectra: a comparison of classification using whole spectra versus metabolite quantification
Opstad KS;Ladroue C;Bell BA;Griffiths JR;Howe FA
NMR Biomed 2007; 20 (8):763-770.

Assessment of tumor response to the vascular disrupting agents 5,6-dimethylxanthenone-4-acetic acid or combretastatin-a4-phosphate by intrinsic susceptibility magnetic resonance imaging
Mcphail LD;Griffiths JR;Robinson SP
Int J Radiat Oncol Biol Phys 2007; 69 (4):1238-1245.

Susceptibility contrast magnetic resonance imaging determination of fractional tumor blood volume: A noninvasive imaging biomarker of response to the vascular disrupting agent ZD6126
Robinson SP;Howe FA;Griffiths JR;Ryan AJ;Waterton JC
Int J Radiat Oncol Biol Phys 2007; 69 (3):872-879.

Correlations between MRS and DTI in cerebral small vessel disease
Nitkunan A;McIntyre DJO;Barrick TR;O'Sullivan M;Shen YJ;Clark CA;Howe FA;Markus HS
NMR Biomed 2006; 19 (5):610-616.

Evaluation of P-31 high-resolution magic angle spinning of intact tissue samples
Payne GS;Troy H;Vaidya SJ;Griffiths JR;Leach MO;Chung YL
NMR Biomed 2006; 19 (5):593-598.

Rat tumor response to the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid as measured by dynamic contrast-enhanced magnetic resonance imaging, plasma 5-hydroxyindoleacetic acid levels, and tumor necrosis
McPhail LD;McIntyre DJO;Ludwig C;Kestell P;Griffiths JR;Kelland LR;Robinson SP
Neoplasia 2006; 8 (3):199-206.

Response of RIF-1 fibrosarcomas to the vascular-disrupting agent ZD6126 assessed by in vivo and ex vivo H-1 magnetic resonance spectroscopy
Madhu B;Waterton JC;Griffiths JR;Ryan AJ;Robinson SP
Neoplasia 2006; 8 (7):560-567.

Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra
Tate AR;Underwood J;Acosta DM;Julia-Sape M;Majos C;Moreno-Torres A;Howe FA;Graaf MV;Lefournier V;Murphy MM;Loosemore A;Ladroue C;Wesseling P;Bosson JL;Cabanas ME;Simonetti AW;Gajewicz W;Calvar J;Capdevila A;Wilkins PR;Bell BA;Remy C;Heerschap A;Watson D;Griffiths JR;Arus C
NMR Biomed 2006; 19 (4):411-434.

In vivo P-31 MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial
Arias-Mendoza F;Payne GS;Zakian KL;Schwarz AJ;Stubbs M;Stoyanova R;Ballon D;Howe FA;Koutcher JA;Leach MO;Griffiths JR;Heerschap A;Glickson JD;Nelson SJ;Evelhoch JL;Charles HC;Brown TR;Cooperative Grp MRS
NMR Biomed 2006; 19 (4):504-512.

Comparison between neuroimaging classifications and histopathological diagnoses using an international multicenter brain tumor magnetic resonance imaging database
Julia-Sape M;Acosta D;Majos C;Moreno-Torres A;Wesseling P;Acebes JJ;Griffiths JR;Arus C
J Neurosurg 2006; 105 (1):6-14.

A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombe
Weeks ME;Sinclair J;Butt A;Chung YL;Worthington JL;Wilkinson CRM;Griffiths J;Jones N;Waterfield MD;Timms JF
Proteomics 2006; 6 (9):2772-2796.

Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies
Workman P;Aboagye EO;Chung YL;Griffiths JR;Hart R;Leach MO;Maxwell RJ;McSheehy PMJ;Price PM;Zweit J;Canc Res UK Pharmacodynamic Pharma
J Natl Cancer Inst 2006; 98 (9):580-598.

Tumor overexpression of inducible nitric oxide synthase (NOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126
Cullis ER;Kalber TL;Ashton SE;Cartwright JE;Griffiths JR;Ryan AJ;Robinson SP
Microvasc Res 2006; 71 (2):76-84.

White matter damage on diffusion tensor imaging correlates with age-related cognitive decline
Charlton RA;Barrick TR;McIntyre DJ;Shen Y;O'Sullivan M;Howe FA;Clark CA;Morris RG;Markus HS
Neurology 2006; 66 (2):217-222.

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models
Al-Saffar NMS;Troy H;de Molina AR;Jackson LE;Madhu B;Griffiths JR;Leach MO;Workman P;Lacal JC;Judson IR;Chung YL
Cancer Res 2006; 66 (1):427-434.

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
Isaacs JS;Jung YJ;Mole DR;Lee S;Torres-Cabala C;Chung YL;Merino M;Trepel J;Zbar B;Toro J;Ratcliffe PJ;Linehan WM;Neckers L
Cancer Cell 2005; 8 (2):143-153.

Metabolic profiling of hypoxia-inducible factor-1beta-deficient and wild type Hepa-1 cells: effects of hypoxia measured by 1H magnetic resonance spectroscopy.
Troy H;Chung YL;Mayr M;Ly L;Williams K;Stratford I;Harris A;Griffiths J;Stubbs M
Metabolomics 2005; 1 (4):293-303.
DOI: 10.1007/s11306-005-0009-8.

The effects of tumour blood flow and oxygenation modifiers on subcutaneous tumours as determined by NIRS
Howe FA;Connelly JP;Robinson SP;Springett R;Griffiths JR
Adv Exp Med Biol 2005; 566 ():75-81.

A longitudinal study of R-2* and R-2 magnetic resonance imaging relaxation rate measurements in murine liver after a single administration of 3 different iron oxide-based contrast agents
Kalber TL;Smith CJ;Howe FA;Griffiths JR;Ryan AJ;Waterton JC;Robinson SP
Invest Radiol 2005; 40 (12):784-791.

PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.
Porstmann T;Griffiths B;Chung Y-L;Delpuech O;Griffiths JR;Downward J;Schulze A
Oncogene 2005; 24 (43):6465-6481.
DOI: 10.1038/sj.onc.1208802.

Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism
Mayr M;Chung YL;Mayr U;Yin XK;Ly L;Troy H;Fredericks S;Hu YH;Griffiths JR;Xu QB
Arterioscler Thromb Vasc Biol 2005; 25 (10):2135-2142.

Accumulation of Krebs cycle intermediates and over-expression of HIF1 alpha in tumours which result from germline FH and SDH mutations.
Pollard PJ;Briere JJ;Alam NA;Barwell J;Barclay E;Wortham NC;Hunt T;Mitchell M;Olpin S;Moat SJ;Hargreaves IP;Heales SJ;Chung YL;Griffiths JR;Dalgleish A;McGrath JA;Gleeson MJ;Hodgson SV;Poulsom R;Rustin P;Tomlinson IPM
Hum Mol Genet 2005; 14 (15):2231-2239.

Acute tumor response to ZD6126 assessed by intrinsic susceptibility magnetic resonance imaging
Robinson SP;Kalber TL;Howe FA;McIntyre DJO;Griffiths JR;Blakey DC;Whittaker L;Ryan AJ;Watertont JC
Neoplasia 2005; 7 (5):466-474.

Tumor dose response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid, using in vivo magnetic resonance spectroscopy
McPhail LD;Chung YL;Madhu B;Clark S;Griffiths JR;Kelland LR;Robinson SP
Clin Cancer Res 2005; 11 (10):3705-3713.

Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours
McSheehy PMJ;Port RE;Rodrigues LM;Robinson SP;Stubbs M;van der Borns K;Peters GJ;Judson IR;Leach MO;Griffiths JR
Cancer Chemother Pharmacol 2005; 55 (2):117-128.

The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations
Leach MO;Brindle KM;Evelhoch JL;Griffiths JR;Horsman MR;Jackson A;Jayson GC;Judson IR;Knopp MV;Maxwell RJ;McIntyre D;Padhani AR;Price P;Rathbone R;Rustin GJ;Tofts PS;Tozer GM;Vennart W;Waterton JC;Williams SR;Workman P
Br J Cancer 2005; 92 (9):1599-1610.

The C-neu mammary carcinoma in Oncomice; characterization and monitoring response to treatment with herceptin by magnetic resonance methods
Rodrigues LM;Stubbs M;Robinson SP;Newell B;Mansi J;Griffiths JR
Magn Reson Mater Phys Biol Med 2004; 17 (3-6):260-270.

In vivo determination of tumor oxygenation during growth and in response to carbogen breathing using 15C5-loaded alginate capsules as fluorine-19 magnetic resonance imaging oxygen sensors
Noth U;Rodrigues LM;Robinson SP;Jork A;Zimmermann U;Newell B;Griffiths JR
Int J Radiat Oncol Biol Phys 2004; 60 (3):909-919.