Douglas Winton publications

Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift
Lopez-Garcia C;Klein AM;Simons BD;Winton DJ
Science 2010; 330 (6005):822-825.
PubMed;  DOI: 10.1126/science.1196236.

Characterization of a heat resistant beta-glucosidase as a new reporter in cells and mice
McCutcheon SC;Jones K;Cumming SA;Kemp R;Ireland-Zecchini H;Saunders JC;Houghton CA;Howard LA;Winton DJ
BMC Biol 2010; 8 ():89.
UKPubMed (open access);  PubMed;  DOI: 10.1186/1741-7007-8-89.

A historical analysis of herpes simplex virus promoter activation in vivo reveals distinct populations of latently infected neurones
Proenca JT;Coleman HM;Connor V;Winton DJ;Efstathiou S
J Gen Virol 2008; 89 (Pt 12):2965-2974.

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation
Marsh V;Winton DJ;Williams GT;Dubois N;Trumpp A;Sansom OJ;Clarke AR
Nat Genet 2008; 40 (12):1436-1444.
PubMed;  DOI: 10.1038/ng.256.

Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice
Luo F;Brooks DG;Ye H;Hamoudi R;Poulogiannis G;Patek CE;Winton DJ;Arends MJ
Oncogene 2007; 26 (30):4415-4427.

A single type of progenitor cell maintains normal epidermis
Clayton E;Doupe DP;Klein AM;Winton DJ;Simons BD;Jones PH
Nature 2007; 446 (7132):185-189.

Apc deficiency predisposes to renal carcinoma in the mouse
Sansom OJ;Griffiths DFR;Reed KR;Winton DJ;Clarke AR
Oncogene 2005; 24 (55):8205-8210.

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells
Hay T;Patrick T;Winton D;Sansom OJ;Clarke AR
Oncogene 2005; 24 (23):3842-3846.

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine
Sansom OJ;Reed KR;van de Wetering M;Muncan V;Winton DJ;Clevers H;Clarke AR
J Biol Chem 2005; 280 (31):28463-28467.

Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells
Zecchini V;Domaschenz R;Winton D;Jones P
Genes Dev 2005; 19 (14):1686-1691.

Cellular inheritance of a Cre-activated reporter gene to determine Paneth cell longevity in the murine small intestine
Ireland H;Houghton C;Howard L;Winton DJ
Dev Dyn 2005; 233 (4):1332-1336.

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
van Es JH;van Gijn ME;Riccio O;van den Born M;Vooijs M;Begthel H;Cozijnsen M;Robine S;Winton DJ;Radtke F;Clevers H
Nature 2005; 435 (7044):959-963.

PPAR delta status and Apc-mediated tumourigenesis in the mouse intestine
Reed KR;Sansom OJ;Hayes AJ;Gescher AJ;Winton DJ;Peters JM;Clarke AR
Oncogene 2004; 23 (55):8992-8996.

Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity
Kemp R;Ireland H;Clayton E;Houghton C;Howard L;Winton DJ
Nucleic Acids Res 2004; 32 (11):e92.

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
Sansom OJ;Reed KR;Hayes AJ;Ireland H;Brinkmann H;Newton IP;Batlle E;Simon-Assmann P;Clevers H;Nathke IS;Clarke AR;Winton DJ
Genes Dev 2004; 18 (12):1385-1390.

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: Effect of loss of beta-catenin
Ireland H;Kemp R;Houghton C;Howard L;Clarke AR;Sansom OJ;Winton DJ
Gastroenterology 2004; 126 (5):1236-1246.